An unclean night guard can harbor all kinds of bacteria, yeasts and molds. These microorganisms can, cause infections and promote tooth decay and gum disease. When you take your guard out in the morning, brush it with a soft toothbrush (use a different one than the one you use for your teeth) and some liquid antibacterial soap or dish detergent. These mild household cleaners work just as well as the soaking solutions marketed specifically for oral appliances. Use warm, never hot water because the heat can warp the guard and ruin it. Dry it thoroughly before putting it in its case. There is no point in putting a clean guard into a dirty case, so wash and dry the case as well. Before you put your guard back in your mouth, make sure to brush and floss your teeth,  otherwise you will be transferring thousands of microorganisms along with food debris and sugar from your mouth to your guard.

As you need routine checkups so does your nightguard. When you go in for regular exams and cleanings, always bring your guard along so your dentist can examine the fit and evaluate the wear and tear of the guard.